Fluorescence lifetime imaging can reveal the high-resolution structure of various biophysical and chemical parameters in a microenvironment quantitatively. However, the depth of imaging is generally limited to hundreds of micrometers due to aberration and light scattering in biological tissues. This paper introduces an iterative multi-photon adaptive compensation technique (IMPACT) into a two-photon fluorescence lifetime microscopy system to successfully overcome aberrations and multiple scattering problems in deep tissues. It shows that 400 correction modes can be achieved within 5 min, which was mainly limited by the frame rate of a spatial light modulator. This system was used for high-resolution imaging of mice brain tissue and live zebrafish, further verifying its superior performance in imaging quality and photon accumulation speed.

We demonstrate a stable narrow linewidth single-frequency erbium-doped fiber laser (EDFL) operating at 1.6 µm. A Fabry–Perot fiber Bragg grating and two cascaded subrings are incorporated in the main ring cavity to achieve single-frequency operation. The experimentally measured optical signal-to-noise ratio is greater than 73 dB. Furthermore, the linewidth of the EDFL is measured to be about 480 Hz by the self-built short-delayed self-heterodyne interferometry device. The laser shows superior stability, with no mode-hopping during the 60-min observation period. The proposed EDFL provides a new experimental idea for realizing a single-frequency fiber laser in the L-band.

This Letter proposes a high-security modulation scheme for optical transmission systems. By using multi-constellation shaping and asymmetric encryption, the information security can be enhanced and quantum computer cracking can be effectively resisted. Three-dimensional (3D) carrier-less amplitude phase modulation is utilized to superposition and transmit 3D signals. Experimental verification is conducted using a seven-core weakly coupled fiber platform. The results demonstrate that the proposed scheme can effectively protect the system from any illegal attacker.

We propose a neural network equalization delta-sigma modulation (DSM) technique. After performing DSM on the multi-order quadrature amplitude modulation (QAM) orthogonal frequency division multiplexing (OFDM) signal at the transmitting end, neural network equalizer technology is used in the digital signal processing at receiving end. Applying this technology to a 4.6 km W-band millimeter wave system, it is possible to achieve a 1 Gbaud 8192-QAM OFDM signal transmission. The data rate reached 23.4 Gbit/s with the bit error rate at 3.8 × 10^-2, lower than soft-decision forward-error correction threshold (4 × 10^-2).